Protective Role of Tinospora Cordifolia against Cisplatin- Induced Nephrotoxicity
نویسندگان
چکیده
The importance of Tinospora cordifolia stem extract was investigated for its possible curative effect in male wistar rats against the cisplatin induced nephrotoxicity. Oral administration of plant extract cured the cisplatin induced kidney damage. There was an increase in serum creatinine, blood urea nitrogen and alkaline phosphatase in rats treated with Cisplatin (5mg/kg body weight, i.p). Administration of Cisplatin followed by alcoholic extract of Tinospora cordifolia (500mg/kg body weight, p.o) decreased the increased levels of serum creatinine, blood urea nitrogen and alkaline phosphatase in rats. These biochemical observations were supplemented by histopathological examination of kidney section. Results of this study revealed that the alcoholic stem extract of Tinospora cordifolia has curative action against Cisplatin induced nephrotoxicity.
منابع مشابه
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